Article
Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele.
Proceedings of the National Academy of Sciences of the United States of America - 7 Dec 2004
Graveel Carrie, Su Yanli, Koeman Julie, Wang Ling-Mei, Tessarollo Lino, Fiscella Michele, Birchmeier Carmen, Swiatek Pamela, Bronson Roderick, Vande Woude George
Abstract excerpt
Tyrosine kinase-activating mutations in Met have been observed in hereditary papillary renal carcinomas as well as in other cancers. These mutations have been examined in several in vitro systems, where they cause constitutive Met activation, focus formation, and cell motility, and are tumorigenic in xenografts. To study the influence of these mutations on tumorigenesis in vivo, we generated mice with targeted...
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