Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mouse model of activating Met mutations.

Cell cycle (Georgetown, Tex.) - 1 Apr 2005

Graveel Carrie R, London Cheryl A, Vande Woude George F

Abstract excerpt

Tyrosine kinase-activating mutations in Met have been observed in hereditary papillary renal carcinomas (HPRC) and their transforming potential has been examined both in vitro and in tumor xenografts. To study the influence of these mutations in the mouse germline, we generated mice with targeted mutations in the murine met locus. Five mouse lines with mutant Met were created: WT, D1226N, Y1228C, M1248T, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Substrate Specificity
Share to Proto-Oncogene Proteins
Share to Proto-Oncogene Proteins c-met

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptors, Growth Factor

Share to Chromosomes

Share to Disease Progression

Share to Neoplasm Transplantation

Source

Identifiers

PMID: 15738649
DOI: 10.4161/cc.4.4.1590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mouse model of activating Met mutations.PMID 15738649Read ↗

Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele.Semantic proximity Read ↗

MET in human cancer: germline and somatic mutationsSemantic proximity Read ↗

Activating mutations for the Met tyrosine kinase receptor in human cancerSemantic proximity Read ↗

Mouse models in the era of large human tumour sequencing studies.Semantic proximity Read ↗

Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma.Semantic proximity Read ↗

Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance.Semantic proximity Read ↗

Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET InhibitorsSemantic proximity Read ↗

Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion.Semantic proximity Read ↗

Recent Progress in Mouse Models for Tumor Suppressor Genes and its Implications in Human CancerSemantic proximity Read ↗

Integrated sequence and gene expression analysis of mouse models of breast cancer reveals critical events with human parallelsSemantic proximity Read ↗

Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.Semantic proximity Read ↗

A Mouse Model System to Genetically Dissect the Molecular Mechanisms Regulating TumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.