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Article

Polymorphism of the fractalkine receptor CX3CR1 and systemic sclerosis-associated pulmonary arterial hypertension.

Clinical & developmental immunology - 1 Dec 2005

Marasini Bianca, Cossutta Roberta, Selmi Carlo, Pozzi Maria Rosa, Gardinali Marco, Massarotti Marco, Erario Maddalena, Battaglioli Lodovica, Biondi Maria Luisa

Abstract excerpt

Fractalkine (FKN) and its receptor CX3CR1 are critical mediators in the vascular and tissue damage of several chronic diseases, including systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH). Interestingly, the V249I and T280M genetic polymorphisms influence CX3CR1 expression and function. We investigated whether these polymorphisms are associated with PAH secondary to SSc. CX3CR1 genotypes were...

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Share to CX3C Chemokine Receptor 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Share to Scleroderma, Systemic

Source

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Identifiers

PMID: 16584113
DOI: 10.1080/17402520500303297
PMCID: PMC2270742

Genes

PAH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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