Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis.

doi:10.1136/annrheumdis-2011-200986

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Article

Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis.

Annals of the rheumatic diseases - 1 Jun 2012

Manetti Mirko, Allanore Yannick, Saad Mohamad, Fatini Cinzia, Cohignac Vanessa, Guiducci Serena, Romano Eloisa, Airó Paolo, Caramaschi Paola, Tinazzi Ilaria, Riccieri Valeria, Della Rossa Alessandra, Abbate Rosanna, Caporali Roberto, Cuomo Giovanna, Valesini Guido, Dieudé Philippe, Hachulla Eric, Cracowski Jean-Luc, Tiev Kiet, Letenneur Luc, Amouyel Philippe, Lambert Jean-Charles, Chiocchia Gilles, Martinez Maria, Ibba-Manneschi Lidia, Matucci-Cerinic Marco

Abstract excerpt

OBJECTIVE: Caveolin-1 (CAV1) is an inhibitor of tissue fibrosis and has been implicated in the pathogenesis of systemic sclerosis (SSc). The aim of the study was to analyse the possible association of CAV1 gene single nucleotide polymorphisms (SNP) with SSc. METHODS: A total population of 3974 individuals (1355 SSc patients, 2619 controls) was studied. Genotype data for 23 SNP spanning the CAV1-CAV2 gene locus...

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PMID: 22402147
DOI: 10.1136/annrheumdis-2011-200986

Genes

CAV1
CAV2

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