CX3CR1 is a modifying gene of survival and progression in amyotrophic lateral sclerosis.

doi:10.1371/journal.pone.0096528

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Article

CX3CR1 is a modifying gene of survival and progression in amyotrophic lateral sclerosis.

PloS one - 1 Jan 2014

Lopez-Lopez Alan, Gamez Josep, Syriani Emilio, Morales Miguel, Salvado Maria, Rodríguez Manuel J, Mahy Nicole, Vidal-Taboada Jose M

Abstract excerpt

The objective of this study was to investigate the association of functional variants of the human CX3CR1 gene (Fractalkine receptor) with the risk of Amyotrophic Lateral Sclerosis (ALS), the survival and the progression rate of the disease symptoms in a Spanish ALS cohort. 187 ALS patients (142 sporadic [sALS] and 45 familial) and 378 controls were recruited. We investigated CX3CR1 V249I (rs3732379) and T280M...

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PMID: 24806473
DOI: 10.1371/journal.pone.0096528
PMCID: PMC4013026

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