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Article

Structural determinants for substrate binding and catalysis by the structure-specific endonuclease XPG.

The Journal of biological chemistry - 23 May 2003

Hohl Marcel, Thorel Fabrizio, Clarkson Stuart G, Schärer Orlando D

Abstract excerpt

XPG belongs to the Fen1 family of structure-specific nucleases and is responsible for the 3' endonucleolytic incision during mammalian nucleotide excision repair. In addition, it has ill-defined roles in the transcription-coupled repair of oxidative DNA damage and likely also in transcription that are independent of its nuclease activity. We have used DNA binding and footprinting assays with various substrates to...

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PMID: 12644470
DOI: 10.1074/jbc.M213155200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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