Article
Cognitive performance of patients with mesial temporal lobe epilepsy is not associated with human prion protein gene variant allele at codons 129 and 171.
Epilepsy & behavior : E&B - 1 May 2006
Coimbra Erica R, Rezek Karinne, Escorsi-Rosset Sara, Landemberger Michele C, Castro Rosa M R P S, Valadão Michelle N, Guarnieri Ricardo, Velasco Tonicarlo R, Terra-Bustamante Vera C, Bianchin Marino M, Wichert-Ana Lauro, Alexandre Veriano, Brentani Ricardo R, Martins Vilma R, Sakamoto Américo C, Walz Roger
Abstract excerpt
Cognitive impairment has long been recognized in people with medically refractory epilepsies. Mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS), the most common surgically remediable epileptic syndrome, has been associated with a cellular prion protein (PrPc) gene (Prnp) variant allele at codon 171. The polymorphism consisting of a methionine-for-valine substitution at codon 129 has been...
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