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Article

Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD.

Neurology - 22 Aug 2000

Combarros O, Sánchez-Guerra M, Llorca J, Alvarez-Arcaya A, Berciano J, Peña N, Fernández-Viadero C

Abstract excerpt

An association between cognitive performance in elderly people and variability in the codon 129 of the prion protein gene (PRNP) has been recently described. The authors analyzed this polymorphism in 278 sporadic AD patients and 268 cognitively normal control subjects. Analyses stratifying by APOE genotype, age, and gender failed to reveal any association between homozygosity for the 129 PRNP methionine or valine...

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Source

Identifiers

PMID: 10953203
DOI: 10.1212/wnl.55.4.593

Genes

PRNP
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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