Article
Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant.
Neurology - 11 Nov 2003
Walz R, Castro R M R P S, Velasco T R, Alexandre V, Lopes M H, Leite J P, Santos A C, Assirati J A, Wichert-Ana L, Terra-Bustamante V C, Bianchin M M, Maciag P C, Ribeiro K B, Guarnieri R, Araújo D, Cabalero O, Moura R, Salim A C M, Kindlmann K, Landemberger M C, Marques W, Fernandes R M F, Serafini L N, Machado H R, Carlotti C G, Brentani R R, Sakamoto A C, Martins V R
Abstract excerpt
BACKGROUND: Mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) is the most common surgically remediable epileptic syndrome. Ablation of the cellular prion protein (PrP(c)) gene (PRNP) enhances neuronal excitability of the hippocampus in vitro and sensitivity to seizure in vivo, indicating that PrP(c) might be related to epilepsy. OBJECTIVE: To evaluate the genetic contribution of PRNP to...
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