Polymorphism of the prion protein is associated with cognitive impairment in the elderly: the EVA study.

doi:10.1212/wnl.51.3.734

Back to search

Article

Polymorphism of the prion protein is associated with cognitive impairment in the elderly: the EVA study.

Neurology - 1 Sept 1998

Berr C, Richard F, Dufouil C, Amant C, Alperovitch A, Amouyel P

Abstract excerpt

BACKGROUND: Little is known about the role of the prion protein (PrP(sen)/gene PRNP). PRNP knockout mice studies suggest that PrP(sen) may be involved in CNS degeneration. This observation prompted us to examine the influence of PRNP genetic variability on cognitive abilities in the elderly. METH...

Topics

Age Factors
Aged
Alleles
Apolipoproteins E
Cognition Disorders
Education
Female
Genotype
Humans
Male
Middle Aged
Polymorphism, Genetic
Prions
Psychological Tests

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.