Article
M129V polymorphism in the prion protein gene is not associated with mesial temporal lobe epilepsy in a Han Chinese population.
European journal of neurology - 1 Aug 2008
Wang X, Sun W, Zhu X, Wu X, Li L, Zhu S, Du T, Liu Y, Niu N, Wang Y, Liu Y
Abstract excerpt
BACKGROUND AND PURPOSE: Prion protein (PrP) predominantly localized at synapses can modulate neuronal excitability. The prion protein gene (PRNP) has been considered one of the candidate genes that play a role in seizure susceptibility. A recent study demonstrated that the 129V allele in the PRNP gene was associated with susceptibility to temporal lobe epilepsy (TLE) in female patients in an Italian population....
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