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Article

The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects.

Journal of neurology - 1 Jun 2003

Del Bo Roberto, Comi Giacomo Pietro, Giorda Roberto, Crimi Marco, Locatelli Federica, Martinelli-Boneschi Filippo, Pozzoli Uberto, Castelli Enrico, Bresolin Nereo, Scarlato Guglielmo

Abstract excerpt

Recently, a frequent prion protein gene (PRNP) polymorphism consisting of a methionine (M) for valine (V) substitution at codon 129 has been associated with cognitive impairment in elderly individuals. Down syndrome (DS) is associated with mental retardation and development of Alzheimer-like brai...

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Source

Identifiers

PMID: 12796830
DOI: 10.1007/s00415-003-1057-5

Genes

PRNP
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12796830-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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The 129 codon polymorphism of the prion protein gene influences earlier cognitive performance in Down syndrome subjects.PMID 12796830Read ↗

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