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Article

TAp73alpha induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism.

Neuroscience letters - 19 Jun 2006

Hooper Claudie, Killick Richard, Tavassoli Mahvash, Melino Gerry, Lovestone Simon

Abstract excerpt

p73 and tau both play roles in neurodevelopment and neurodegeneration. In this pilot study we show by Western blotting that TAp73alpha induces phosphorylation of human 2N4R tau at threonine-205 and at the PHF-1 epitope (serine366/serine404) in HEK293a cells. Neither the dominant negative isoform, DeltaNp73, nor a transcriptionally inactive mutant TAp73alpha(R292H) altered tau phosphorylation indicating that tau...

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Identifiers

PMID: 16580132
DOI: 10.1016/j.neulet.2006.02.082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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