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Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice

15 Apr 2002

Abstract excerpt

Genomic imprinting is regulated by differential methylation of the paternal and maternal genome. However, it remains unknown how parental imprinting is established during gametogenesis. In this study, we demonstrate that Dnmt3L, a protein sharing homology with DNA methyltransferases, Dnmt3a and Dnmt3b, but lacking enzymatic activity, is essential for the establishment of maternal methylation imprints and...

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Share to Epigenetics and DNA Methylation
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PMID: 11934864
DOI: 10.1242/dev.129.8.1983

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Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in micePMID 11934864Read ↗

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.Semantic proximity Read ↗

Dnmt3L and the establishment of maternal genomic imprints.Semantic proximity Read ↗

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Haploinsufficiency of the paternal-effect gene Dnmt3L results in transient DNA hypomethylation in progenitor cells of the male germline.Semantic proximity Read ↗

DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription.Semantic proximity Read ↗

Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo.Semantic proximity Read ↗

The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3aSemantic proximity Read ↗

Loss of the maternal imprint in Dnmt3L mice leads to a differentiation defect in the extraembryonic tissueSemantic proximity Read ↗

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Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3BSemantic proximity Read ↗

Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline.Semantic proximity Read ↗

DNMT3L Stimulates the DNA Methylation Activity of Dnmt3a and Dnmt3b through a Direct InteractionSemantic proximity Read ↗

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