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Article

Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6.

European journal of immunology - 1 Jan 2005

Rückerl Florian, Bachl Jurgen

Abstract excerpt

Activation-induced cytidine deaminase (AID) plays a key role in the induction of somatic hypermutation and class switching at the immunoglobulin loci of B lymphocytes. AID overexpression can induce a mutator phenotype in lymphoid and nonlymphoid cell lines, suggesting that AID by itself is sufficient to trigger hypermutation and class switching. AID expression in vivo is considered to be restricted to germinal...

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Identifiers

PMID: 15593119
DOI: 10.1002/eji.200425315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation-induced cytidine deaminase fails to induce a mutator phenotype in the human pre-B cell line Nalm-6.PMID 15593119Read ↗

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Epigenetic Function of Activation-Induced Cytidine Deaminase and Its Link to LymphomagenesisSemantic proximity Read ↗

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Genome-wide somatic hypermutation.Semantic proximity Read ↗

Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks.Semantic proximity Read ↗

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