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Article

Timing of the steps in transformation of C3H 10T 1/2 cells by X-irradiation.

Nature - 1 Jan 2000

Kennedy A R, Cairns J, Little J B

Abstract excerpt

Transformation of cells in culture by chemical carcinogens or X rays seems to require at least two steps. The initial step is a frequent event; for example, after transient exposure to either methylcholanthrene or X rays, almost every cell of established lines of mouse embryo fibroblasts proved capable of yielding transformed, tumorigenic descendants. Although results were interpreted as indicating that 100% of...

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PMID: 6690989
DOI: 10.1038/307085a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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