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Article

Reverse genetics-generated elastase-dependent swine influenza viruses are attenuated in pigs.

The Journal of general virology - 1 Feb 2009

Masic Aleksandar, Babiuk Lorne A, Zhou Yan

Abstract excerpt

Influenza A virus causes significant morbidity in swine, resulting in a substantial economic burden. Swine influenza virus (SIV) infection also poses important human public health concerns. It has been shown that conversion of the haemagglutinin (HA) cleavage site from a trypsin-sensitive motif to an elastase-sensitive motif resulted in attenuated viruses in mouse models. However, application of this attenuation...

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Share to Hemagglutinins, Viral
Share to Influenza A Virus, H1N1 Subtype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19141446
DOI: 10.1099/vir.0.005447-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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