Host defense mechanism-based rational design of live vaccine.

doi:10.1371/journal.pone.0075043

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Article

Host defense mechanism-based rational design of live vaccine.

PloS one - 1 Jan 2013

Jang Yo Han, Byun Young Ho, Lee Kwang-Hee, Park Eun-Sook, Lee Yun Ha, Lee Yoon-Jae, Lee Jinhee, Kim Kyun-Hwan, Seong Baik Lin

Abstract excerpt

Live attenuated vaccine (LAV), mimicking natural infection, provides an excellent protection against microbial infection. The development of LAV, however, still remains highly empirical and the rational design of clinically useful LAV is scarcely available. Apoptosis and caspase activation are general host antiviral responses in virus-infected cells. Utilizing these tightly regulated host defense mechanisms, we...

Topics

Amino Acid Sequence
Animals
Base Sequence
Caspases
Cell Line
Dogs
Female
Humans
Influenza A virus
Mice
Mutation
Nucleotide Motifs
Ovum
Proteolysis
Vaccines, Attenuated
Viral Proteins

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Identifiers

PMID: 24098364
DOI: 10.1371/journal.pone.0075043
PMCID: PMC3788757

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