Evaluation of a protease activation mutant of Sendai virus as a potent live vaccine.

doi:10.1016/0378-1135(92)90089-c

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Article

Evaluation of a protease activation mutant of Sendai virus as a potent live vaccine.

Veterinary microbiology - 1 Jan 1992

Maru M, Haraguchi M, Sato K, Hotta H, Homma M

Abstract excerpt

A protease activation mutant of Sendai virus, TR-5, was investigated as a candidate for a live vaccine. Vaccination with TR-5 which had been activated by chymotrypsin beforehand (active TR-5) elicited protective immunity against otherwise lethal challenge infection with wild-type Sendai virus in DBA/2, C3H and ICR strains of mice. Less of the active TR-5 was required to confer protection on mice compared with an...

Topics

Administration, Inhalation
Aerosols
Animals
Antibodies, Viral
Female
Hemagglutination Inhibition Tests
Immunization, Secondary
Mice
Mice, Inbred C3H
Mice, Inbred DBA
Mice, Inbred ICR

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Mutation

Parainfluenza Virus 1, Human

Paramyxoviridae Infections

Rodent Diseases

Vaccination

Vaccines, Attenuated

Source

Open in PubMed

Identifiers

PMID: 1311131
DOI: 10.1016/0378-1135(92)90089-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1311131-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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