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Article

Biologic importance of neuraminidase stalk length in influenza A virus

1 Feb 1993

Abstract excerpt

To investigate the biologic importance of the neuraminidase (NA) stalk of influenza A virus, we generated mutant viruses of A/WSN/33 (H1N1) with stalks of various lengths (0 to 52 amino acids), by using the recently developed reverse genetics system. These mutant viruses, including one that lacked the entire stalk, replicated in tissue culture to the level of the parent virus, whose NA stalk contains 24 amino...

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PMID: 8419645
DOI: 10.1128/jvi.67.2.759-764.1993

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