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Article

Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members

29 Mar 2006

Abstract excerpt

Complex airway diseases such as asthma and chronic obstructive pulmonary disease exhibit stereotyped traits (especially airway hyperreactivity and mucous cell metaplasia) that are variably expressed in each patient. Here, we used a mouse model for virus-induced long-term expression of these traits to determine whether individual traits can be genetically segregated and thereby linked to separate determinants. We...

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PMID: 16569774
DOI: 10.1152/physiolgenomics.00321.2005

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