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Central Role of Muc5ac Expression in Mucous Metaplasia and Its Regulation by Conserved 5′ Elements

26 Apr 2007

Abstract excerpt

Mucus hypersecretion contributes to morbidity and mortality in many obstructive lung diseases. Gel-forming mucins are the chief glycoprotein components of airway mucus, and elevated expression of these during mucous metaplasia precedes the hypersecretory phenotype. Five orthologous genes (MUC2, MUC5AC, MUC5B, MUC6, and MUC19) encode the mammalian gel-forming mucin family, and several have been implicated in...

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Identifiers

PMID: 17463395
DOI: 10.1165/rcmb.2005-0460oc

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