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Article

Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease.

mBio - 3 Mar 2020

Lorè Nicola Ivan, Sipione Barbara, He Gengming, Strug Lisa J, Atamni Hanifa J, Dorman Alexandra, Mott Richard, Iraqi Fuad A, Bragonzi Alessandra

Abstract excerpt

Human genetics influence a range of pathological and clinical phenotypes in respiratory infections; however, the contributions of disease modifiers remain underappreciated. We exploited the Collaborative Cross (CC) mouse genetic-reference population to map genetic modifiers that affect the severity of Pseudomonas aeruginosa lung infection. Screening for P. aeruginosa respiratory infection in a cohort of 39 CC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32127447
DOI: 10.1128/mBio.00097-20
PMCID: PMC7064750

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