Article

ΔF508-Cftr mutation in genetically diverse Collaborative Cross mice yields novel disease-relevant phenotypes for cystic fibrosis

2023-02-03

Abstract excerpt

Mutations of Cystic Fibrosis Transmembrane conductance Regulator ( CFTR ) lead to Cystic Fibrosis (CF), but the substantial phenotypic variations are determined by non- CFTR allelic diversity. To map novel disease phenotypes in a CF mouse model, we used Collaborative Cross (CC) mice, a highly genetically diverse mouse resource population. ΔF508-Cftr homozygosity produced a fully penetrant lethal phenotype by e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e152d6c8-3919-5108-a51a-82927160edd6
DOI: 10.1101/2023.01.31.526098

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ΔF508-Cftr mutation in genetically diverse Collaborative Cross mice yields novel disease-relevant phenotypes for cystic fibrosisDOI 10.1101/2023.01.31.526098Read

Mouse models of cystic fibrosis: phenotypic analysis and research applications.Semantic proximity Read

The CF mouse: an important tool for studying cystic fibrosisSemantic proximity Read

The Collaborative Cross mouse model for dissecting genetic susceptibility to infectious diseases.Semantic proximity Read

Cystic fibrosis mouse models.Semantic proximity Read

Mouse models of cystic fibrosis.Semantic proximity Read

The Collaborative Cross, developing a resource for mammalian systems genetics: a status report of the Wellcome Trust cohort.Semantic proximity Read

Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease.Semantic proximity Read

Animal models for cystic fibrosis: a systematic search and mapping review of the literature. Part 2: nongenetic models.Semantic proximity Read

Animal Models of Cystic Fibrosis Pathology: Phenotypic Parallels and DivergencesSemantic proximity Read

Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300Semantic proximity Read

A systems genetics approach to uncover mitochondrial drivers of heart failure reveals mitochondria-nuclear cross talk in genetically diverse mouse strainsSemantic proximity Read

Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations.Semantic proximity Read

<i>ΔF508-Cftr</i> mutation in genetically diverse Collaborative Cross mice yields novel disease-relevant phenotypes for cystic fibrosis

Abstract excerpt

Topics

Identifiers and source

Related research