Article
The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants.
Pharmacogenetics - 1 Oct 2001
Zhang J, Kuehl P, Green E D, Touchman J W, Watkins P B, Daly A, Hall S D, Maurel P, Relling M, Brimer C, Yasuda K, Wrighton S A, Hancock M, Kim R B, Strom S, Thummel K, Russell C G, Hudson J R, Schuetz E G, Boguski M S
Abstract excerpt
The pregnane X receptor (PXR)/steroid and xenobiotic receptor (SXR) transcriptionally activates cytochrome P4503A4 (CYP3A4) when ligand activated by endobiotics and xenobiotics. We cloned the human PXR gene and analysed the sequence in DNAs of individuals whose CYP3A phenotype was known. The PXR gene spans 35 kb, contains nine exons, and mapped to chromosome 13q11-13. Thirty-eight single nucleotide polymorphisms...
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