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Polymorphisms of the protein kinase C-beta gene (PRKCB1) accelerate kidney disease in type 2 diabetes without overt proteinuria.

Diabetes care - 1 Apr 2006

Araki Shin-ichi, Haneda Masakazu, Sugimoto Toshiro, Isono Motohide, Isshiki Keiji, Kashiwagi Atsunori, Koya Daisuke

Abstract excerpt

OBJECTIVE: We investigated the contribution of PKC-beta gene (PRKCB1) polymorphisms to diabetic kidney disease in a prospective observational follow-up study. RESEARCH DESIGN AND METHODS: A total of 364 Japanese subjects with type 2 diabetes without overt proteinuria were enrolled during 1996-1998 and followed until 2004. Five single nucleotide polymorphisms (-1504C/T, -546C/G, -348A/G, -278C/T, and -238C/G) in...

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Identifiers

PMID: 16567829
DOI: 10.2337/diacare.29.04.06.dc05-1723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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