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A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria.

Diabetes - 1 Mar 2000

De Cosmo S, Argiolas A, Miscio G, Thomas S, Piras G P, Trevisan R, Perin P C, Bacci S, Zucaro L, Margaglione M, Frittitta L, Pizzuti A, Tassi V, Viberti G C, Trischitta V

Abstract excerpt

Insulin resistance characterizes type 1 diabetes in patients with albuminuria. A PC-1 glycoprotein amino acid variant, K121Q, is associated with insulin resistance. We examined the impact of the PC-1 K121Q variant on the rate of decline of the glomerular filtration rate (GFR) by creatinine clearance derived from the Cockroft-Gault formula in 77 type 1 diabetic patients with albuminuria who were followed for an...

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Identifiers

PMID: 10868979
DOI: 10.2337/diabetes.49.3.521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria.PMID 10868979Read ↗

PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients.Semantic proximity Read ↗

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Polymorphism in ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene (ENPP1/PC-1) and early development of advanced diabetic nephropathy in type 1 diabetes.Semantic proximity Read ↗

A KQ121 variant in the PC-1 gene and diabetic nephropathy: discrepant results between North and South Europe.Semantic proximity Read ↗

The role of PC-1 and ACE genes in diabetic nephropathy in type 1 diabetic patients: evidence for a polygenic control of kidney disease progression.Semantic proximity Read ↗

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia.Semantic proximity Read ↗

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The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance.Semantic proximity Read ↗

The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121).Semantic proximity Read ↗

The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes.Semantic proximity Read ↗

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