Article
APOE polymorphism and the progression of diabetic nephropathy in Japanese subjects with type 2 diabetes: results of a prospective observational follow-up study.
Diabetes care - 1 Aug 2003
Araki Shin-Ichi, Koya Daisuke, Makiishi Tetsuya, Sugimoto Toshiro, Isono Motohide, Kikkawa Ryuichi, Kashiwagi Atsunori, Haneda Masakazu
Abstract excerpt
OBJECTIVE: The aim of this study is to clarify the conflicting results of the epsilon2/epsilon3/epsilon4 APOE polymorphism as a risk factor on diabetic nephropathy by a cohort study. RESEARCH DESIGN AND METHODS: A total of 429 Japanese subjects with type 2 diabetes and with normoalbuminuria (n = 299) or with microalbuminuria (n = 130) were enrolled in a prospective observational follow-up study during 1995-1998...
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