Article
Protection against diabetes and improved NK/NKT cell performance in NOD.NK1.1 mice congenic at the NK complex.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2001
Carnaud C, Gombert J, Donnars O, Garchon H, Herbelin A
Abstract excerpt
The NK1.1 cell surface receptor, which belongs to the NKR-P1 gene cluster, has been bred onto nonobese diabetic (NOD) mice for two purposes. The first was to tag NK and NKT cells for easier experimental identification of those subsets and better analysis of their implication in type 1 diabetes. The second was to produce a congenic strain carrying Idd6, a susceptibility locus that has been repeatedly mapped in the...
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