Article
The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study.
Diabetes - 1 Apr 2006
Jaziri Riphed, Lobbens Stephane, Aubert Roberte, Péan Franck, Lahmidi Saida, Vaxillaire Martine, Porchay Isabelle, Bellili Naïma, Tichet Jean, Balkau Beverley, Froguel Philippe, Marre Michel, Fumeron Frédéric
Abstract excerpt
Although cross-sectional studies have associated the Pro12Ala polymorphism of PPARG with type 2 diabetes, prospective studies offer more opportunities to investigate genetic variants. Associations between PPARG polymorphisms with insulin resistance parameters and with the 6-year incidence of impaired fasting glucose or type 2 diabetes were tested in 3,914 French Caucasians from the DESIR (Data From an...
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