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Article

Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2004

Doney Alex S F, Fischer Bettina, Leese Graham, Morris Andrew D, Palmer Colin N A

Abstract excerpt

OBJECTIVE: The Pro12Ala polymorphism of PPARG modulates risk of developing type 2 diabetes. The Ala allele has also been associated with a reduced risk of cardiovascular events. We have shown previously that the linked T allele of the C1431T polymorphism influences Ala12-associated diabetes risk...

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Source

Identifiers

PMID: 15486307
DOI: 10.1161/01.ATV.0000147897.57527.e4

Genes

PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15486307-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study.PMID 15486307Read ↗

Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes.Semantic proximity Read ↗

The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study.Semantic proximity Read ↗

Association of the Pro12Ala and C1431T variants of PPARgamma and their haplotypes with susceptibility to gestational diabetes.Semantic proximity Read ↗

The common PPARγ2 Pro12Ala polymorphism is associated with an increased risk of coronary artery disease (CAD) in Iranian patients with type 2 diabetes mellitusSemantic proximity Read ↗

Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.Semantic proximity Read ↗

Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD.Semantic proximity Read ↗

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The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.Semantic proximity Read ↗

Association of the PPARγ2 Pro12Ala polymorphism with increased risk of cardiovascular diseases.Semantic proximity Read ↗

Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight.Semantic proximity Read ↗

Differential effects of the C1431T and Pro12Ala PPARgamma gene variants on plasma lipids and diabetes risk in an Asian population.Semantic proximity Read ↗

Effects of the PPARG P12A and C161T gene variants on serum lipids in coronary heart disease patients with and without Type 2 diabetes.Semantic proximity Read ↗

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