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The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs.

Vaccine - 24 Apr 2006

Martin Carlos, Williams Ann, Hernandez-Pando Rogelio, Cardona Pere J, Gormley Eamonn, Bordat Yann, Soto Carlos Y, Clark Simon O, Hatch Graham J, Aguilar Diana, Ausina Vicente, Gicquel Brigitte

Abstract excerpt

The Mycobacterium tuberculosis phoP mutant strain SO2 has previously been shown to have reduced multiplication in mouse macrophages and in vivo using the mouse intravenous-infection model. In this study we demonstrate that the M. tuberculosis SO2 is highly attenuated when compared with the parental M. tuberculosis MT103 strain and also more attenuated than BCG in severe combined immunodeficiency disease (SCID)...

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Identifiers

PMID: 16564606
DOI: 10.1016/j.vaccine.2006.03.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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