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Mycobacterium bovis mutant in the virulence factors PhoP, ESAT-6 and CFP-10 persisted in mouse organs after a year post-vaccination.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2024

Blanco Federico Carlos, Vázquez Cristina Lourdes, García Elizabeth Andrea, Rocha Rosana Valeria, Klepp Laura Inés, Bigi Fabiana

Abstract excerpt

A vaccine for bovine tuberculosis is urgently needed. The BCG vaccine (the Bacille Calmette-Guérin), currently the only licensed vaccine for tuberculosis in humans, offers variable protection in cattle. However, BCG is a highly safe vaccine, and any alternative vaccine must not only offer greater protection than BCG but also match and improve its safety profile. Mice are the most widely used animal models in...

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PMID: 39509845
DOI: 10.1016/j.tube.2024.102574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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