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Article

Extended safety studies of the attenuated live tuberculosis vaccine SO2 based on phoP mutant.

Vaccine - 21 Apr 2009

Cardona P J, Asensio J Gonzalo, Arbués A, Otal I, Lafoz C, Gil O, Caceres N, Ausina V, Gicquel B, Martin C

Abstract excerpt

Safety is one of the main concerns for attenuated live vaccine candidates. Here we extend the stability and attenuation studies of the promising tuberculosis vaccine candidate based on Mycobacterium tuberculosis phoP mutant strain, SO2. Stability of the phoP mutation was tested after sub-culturing SO2 strain for 6 months in laboratory media and also after 3 months of infection in SCID mice. Results showed no...

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Source

Identifiers

PMID: 19368792
DOI: 10.1016/j.vaccine.2009.02.060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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