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Article

Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs.

Infection and immunity - 1 May 2004

Sampson Samantha L, Dascher Christopher C, Sambandamurthy Vasan K, Russell Robert G, Jacobs William R, Bloom Barry R, Hondalus Mary K

Abstract excerpt

We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The deltaleuD deltapanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protective in the extremely sensitive guinea pig tuberculosis model, reducing both bacterial burden and disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

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Source

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Identifiers

PMID: 15102816
DOI: 10.1128/IAI.72.5.3031-3037.2004
PMCID: PMC387862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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