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Article

Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP.

PLoS pathogens - 8 Feb 2008

Frigui Wafa, Bottai Daria, Majlessi Laleh, Monot Marc, Josselin Emmanuelle, Brodin Priscille, Garnier Thierry, Gicquel Brigitte, Martin Carlos, Leclerc Claude, Cole Stewart T, Brosch Roland

Abstract excerpt

Analysis of mycobacterial strains that have lost their ability to cause disease is a powerful approach to identify yet unknown virulence determinants and pathways involved in tuberculosis pathogenesis. Two of the most widely used attenuated strains in the history of tuberculosis research are Mycobacterium bovis BCG (BCG) and Mycobacterium tuberculosis H37Ra (H37Ra), which both lost their virulence during in vitro...

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Source

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Identifiers

PMID: 18282096
DOI: 10.1371/journal.ppat.0040033
PMCID: PMC2242835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP.PMID 18282096Read ↗

EspR-dependent ESAT-6 Protein Secretion of Mycobacterium tuberculosis Requires the Presence of Virulence Regulator PhoPSemantic proximity Read ↗

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PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis VirulenceSemantic proximity Read ↗

ESAT-6 Secretion-Independent Impact of ESX-1 Genes espF and espG1 on Virulence of Mycobacterium tuberculosisSemantic proximity Read ↗

Phenotypic Profiling of Mycobacterium tuberculosis EspA Point Mutants Reveals that Blockage of ESAT-6 and CFP-10 Secretion <i>In Vitro</i> Does Not Always Correlate with Attenuation of VirulenceSemantic proximity Read ↗

Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator.Semantic proximity Read ↗

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BCG Vaccines: Their mechanisms of attenuation and impact on safety and protective efficacySemantic proximity Read ↗

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Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulatorSemantic proximity Read ↗

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulenceSemantic proximity Read ↗

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteriaSemantic proximity Read ↗

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