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Article

Protective immunity afforded by attenuated, PhoP‐deficient Mycobacterium tuberculosis is associated with sustained generation of CD4+ T‐cell memory

22 Nov 2011

Abstract excerpt

Definition of protective immunity induced by effective vaccines is important for the design of new pathogen control strategies. Inactivation of the PhoP response-regulator in Mycobacterium tuberculosis results in a highly attenuated strain that demonstrates impressive protective efficacy in pre-clinical models of tuberculosis. In this report we demonstrate that the protection afforded by the M. tuberculosis phoP...

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PMID: 22105536
DOI: 10.1002/eji.201141903

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