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Article

PhoP: A Missing Piece in the Intricate Puzzle of Mycobacterium tuberculosis Virulence

22 Oct 2008

Abstract excerpt

Inactivation of the transcriptional regulator PhoP results in Mycobacterium tuberculosis attenuation. Preclinical testing has shown that attenuated M. tuberculosis phoP mutants hold promise as safe and effective live vaccine candidates. We focused this study to decipher the virulence networks regulated by PhoP. A combined transcriptomic and proteomic analysis revealed that PhoP controls a variety of functions...

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PMID: 18946503
DOI: 10.1371/journal.pone.0003496

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