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Article

Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells.

Mutation research - 25 Jul 2006

Bryant Helen E, Ying Songmin, Helleday Thomas

Abstract excerpt

Chromium is a potent human carcinogen, probably because of its well-documented genotoxic effects. Chromate (Cr[VI]) causes a wide range of DNA lesions, including DNA crosslinks and strand breaks, presumably due to the direct and indirect effects of DNA oxidation. Homologous recombination repair (HRR) is important for error-free repair of lesions occurring at replication forks. Here, we show that HR deficient cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16564059
DOI: 10.1016/j.mrfmmm.2006.02.001

Genes

BRCA2
ERCC1
XRCC1
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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