Article
The contribution of homologous recombination in preserving genome integrity in mammalian cells.
Biochimie - 1 Jan 2000
Thompson L H, Schild D
Abstract excerpt
Although it is clear that mammalian somatic cells possess the enzymatic machinery to perform homologous recombination of DNA molecules, the importance of this process in mitigating DNA damage has been uncertain. An initial genetic framework for studying homologous recombinational repair (HRR) has come from identifying relevant genes by homology or by their ability to correct mutants whose phenotypes are...
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