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Article

Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions.

Radiation research - 1 Jan 2010

Zafar Faria, Seidler Sara B, Kronenberg Amy, Schild David, Wiese Claudia

Abstract excerpt

To test the contribution of homologous recombinational repair (HRR) in repairing DNA damage sites induced by high-energy iron ions, we used (1) HRR-deficient rodent cells carrying a deletion in the RAD51D gene and (2) syngeneic human cells impaired for HRR by RAD51D or RAD51 knockdown using RNA interference. We found that in response to exposure to iron ions, HRR contributed to cell survival in rodent cells and...

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Identifiers

PMID: 20041757
DOI: 10.1667/RR1910.1

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RAD51

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