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Article

The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo.

Development (Cambridge, England) - 1 Jan 2006

Chen Canhe, Ware Stephanie M, Sato Akira, Houston-Hawkins Dianne E, Habas Raymond, Matzuk Martin M, Shen Michael M, Brown Chester W

Abstract excerpt

The formation of the anterior visceral endoderm (AVE) in the pre-gastrulation mouse embryo represents a crucial event in patterning of the anterior-posterior axis. Here, we show that the transforming growth factor beta (Tgfbeta) family member Gdf3 (growth-differentiation factor 3), a close relative of Xenopus Vg1, resembles the Tgfbeta ligand Nodal in both its signaling activity and its role in AVE formation in...

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Source

Identifiers

PMID: 16368929
DOI: 10.1242/dev.02210

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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