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Article

Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin.

PLoS genetics - 1 May 2011

Slagle Christopher E, Aoki Tsutomu, Burdine Rebecca D

Abstract excerpt

Vertebrate mesendoderm specification requires the Nodal signaling pathway and its transcriptional effector FoxH1. However, loss of FoxH1 in several species does not reliably cause the full range of loss-of-Nodal phenotypes, indicating that Nodal signals through additional transcription factors during early development. We investigated the FoxH1-dependent and -independent roles of Nodal signaling during...

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Identifiers

PMID: 21637786
DOI: 10.1371/journal.pgen.1002072
PMCID: PMC3102743

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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