Article
Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO.
Nucleic acids research - 25 Sept 1991
Jang K L, Pulverer B, Woodgett J R, Latchman D S
Abstract excerpt
Lytic infection with herpes simplex virus (HSV) results in the repression of most host cell protein synthesis but produces an increased activity of the cellular AP-1 transcription factor. This increase is paralleled by an increase in the transcription rate of the proto-oncogene encoding the AP-1 component, c-Jun resulting in an increase in c-Jun protein in infected cells. The increased AP-1 activity in infected...
Topics
- Binding Sites
- Blotting, Western
- Cell Line
- Gene Expression
- HeLa Cells
- Humans
- Immediate-Early Proteins
- Mutation
- Plasmids
- Proto-Oncogene Mas
- Proto-Oncogene Proteins c-jun