Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of the thymidine kinase promoter by herpes simplex virus type 1 immediate early proteins.

Molecules and cells - 30 Jun 1999

Kwun H J, Yim S W, Lee D H, Jang K L

Abstract excerpt

The herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) gene promoter contains binding sites for the cellular transcription factors such as Spl, CTF, and TFIID, each of which affects basal level expression of the TK gene. The transcription of the TK gene was induced by viral immediate early proteins, ICP0 and ICP4 in an additive manner, but was repressed by ICP22 and ICP27. To gain further insights into the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Proteins
Share to Cricetinae
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Viral

Share to Herpesvirus 1, Human

Share to Immediate-Early Proteins

Share to NFI Transcription Factors

Share to Thymidine Kinase

Source

Identifiers

PMID: 10420986

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of the thymidine kinase promoter by herpes simplex virus type 1 immediate early proteins.PMID 10420986Read ↗

Evidence that the herpes simplex virus immediate early protein ICP27 acts post-transcriptionally during infection to regulate gene expression.Semantic proximity Read ↗

Mutations in the activation region of herpes simplex virus regulatory protein ICP27 can be trans dominant.Semantic proximity Read ↗

Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0.Semantic proximity Read ↗

Binding sites for the herpes simplex virus immediate-early protein ICP4 impose an increased dependence on viral DNA replication on simple model promoters located in the viral genome.Semantic proximity Read ↗

Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27.Semantic proximity Read ↗

The initiator element in a herpes simplex virus type 1 late-gene promoter enhances activation by ICP4, resulting in abundant late-gene expression.Semantic proximity Read ↗

Activation of human herpesvirus 8 (HHV-8) thymidine kinase (TK) TATAA-less promoter by HHV-8 ORF50 gene product is SP1 dependent.Semantic proximity Read ↗

HSV-1 infected cell proteins influence tetracycline-regulated transgene expression.Semantic proximity Read ↗

Characterization of the trans-activation properties of equine herpesvirus 1 EICP0 protein.Semantic proximity Read ↗

Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function.Semantic proximity Read ↗

Transactivation of the HIV-1 LTR by HSV-1 immediate-early genesSemantic proximity Read ↗

Immediate-early expression of the herpes simplex virus type 1 ICP27 transcript is not critical for efficient replication in vitro or in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.