Article
HSV-1 infected cell proteins influence tetracycline-regulated transgene expression.
The journal of gene medicine - 1 Jan 2000
Herrlinger U, Pechan P A, Jacobs A H, Woiciechowski C, Rainov N G, Fraefel C, Paulus W, Reeves S A
Abstract excerpt
BACKGROUND: This study investigates elements of herpes simplex virus type 1 (HSV-1) which influence transgene expression in tetracycline-regulated expression systems. METHODS: Different HSV-1 mutants were used to infect Vero cells that had been transfected with plasmids containing the luciferase gene under the control of tet-off or tet-on tetracycline-regulation systems. RESULTS: The baseline level of luciferase...
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