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Article

Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.

Molecular and cellular biology - 1 Oct 1991

Miura O, D'Andrea A, Kabat D, Ihle J N

Abstract excerpt

A role for tyrosine phosphorylation in the signal-transducing mechanisms of several hematopoietic growth factors has been hypothesized. To extend these observations, we have examined the effects of erythropoietin (Epo) on tyrosine phosphorylation in an Epo-responsive cell that was obtained by transfecting the murine erythropoietin receptor (EpoR) into an interleukin-3 (IL-3)-dependent cell line. By...

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Identifiers

PMID: 1656216
DOI: 10.1128/mcb.11.10.4895-4902.1991
PMCID: PMC361458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.PMID 1656216Read ↗

In vitro phosphorylation of the erythropoietin receptor and an associated protein, pp130.Semantic proximity Read ↗

Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line.Semantic proximity Read ↗

Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.Semantic proximity Read ↗

The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.Semantic proximity Read ↗

Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases.Semantic proximity Read ↗

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.Semantic proximity Read ↗

Amino acid residues 268-276 of the erythropoietin receptor contain an endocytosis motif and are required for erythropoietin-mediated proliferation.Semantic proximity Read ↗

Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo.Semantic proximity Read ↗

A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation.Semantic proximity Read ↗

The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains.Semantic proximity Read ↗

Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit.Semantic proximity Read ↗

Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain.Semantic proximity Read ↗

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