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Article

Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.

Molecular and cellular biology - 1 Apr 1996

Quelle F W, Wang D, Nosaka T, Thierfelder W E, Stravopodis D, Weinstein Y, Ihle J N

Abstract excerpt

The cytoplasmic domain of the erythropoietin receptor (EpoR) contains a membrane-distal region that is dispensable for mitogenesis but is required for the recruitment and tyrosine phosphorylation of a variety of signaling proteins. The membrane-proximal region of 96 amino acids is necessary and sufficient for mitogenesis as well as Jak2 activation, induction of c-fos, c-myc, cis, the T-cell receptor gamma locus...

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Identifiers

PMID: 8657137
DOI: 10.1128/MCB.16.4.1622
PMCID: PMC231148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.PMID 8657137Read ↗

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Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function.Semantic proximity Read ↗

Regulation of erythropoietin-induced STAT serine phosphorylation by distinct mitogen-activated protein kinases.Semantic proximity Read ↗

STAT5 Activation Is Critical for the Transformation Mediated by Myeloproliferative Disorder-associated JAK2 V617F MutantSemantic proximity Read ↗

Mutations in the Trp-Ser-X-Trp-Ser motif of the erythropoietin receptor abolish processing, ligand binding, and activation of the receptor.Semantic proximity Read ↗

Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit.Semantic proximity Read ↗

The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction.Semantic proximity Read ↗

Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain.Semantic proximity Read ↗

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.Semantic proximity Read ↗

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Amino acid residues 268-276 of the erythropoietin receptor contain an endocytosis motif and are required for erythropoietin-mediated proliferation.Semantic proximity Read ↗

Profiling of early gene expression induced by erythropoietin receptor structural variants.Semantic proximity Read ↗

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