Article
Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.
Molecular and cellular biology - 1 Apr 1996
Quelle F W, Wang D, Nosaka T, Thierfelder W E, Stravopodis D, Weinstein Y, Ihle J N
Abstract excerpt
The cytoplasmic domain of the erythropoietin receptor (EpoR) contains a membrane-distal region that is dispensable for mitogenesis but is required for the recruitment and tyrosine phosphorylation of a variety of signaling proteins. The membrane-proximal region of 96 amino acids is necessary and s...
Topics
- Amino Acid Sequence
- Animals
- Cell Division
- Cell Line
- DNA-Binding Proteins
- Enzyme Activation
- Erythropoietin
- Humans
- Janus Kinase 2
- Milk Proteins
- Molecular Sequence Data
- Mutation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins