Article
A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation.
Experimental hematology - 1 Jan 1999
Arcasoy M O, Harris K W, Forget B G
Abstract excerpt
The erythropoietin receptor (EpoR) has been previously shown to contain a cytoplasmic C-terminal negative regulatory domain, experimental deletion or mutation of which leads to increased sensitivity of expressing cells to the effects erythropoietin (Epo). We have studied a naturally occurring C-t...
Topics
- Animals
- Cell Line
- Cell Nucleus
- DNA-Binding Proteins
- Enzyme Activation
- Erythropoietin
- Family Health
- Humans
- Janus Kinase 2
- Mice
- Milk Proteins
- Mutation
- Phosphorylation