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Article

Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain.

Biochimica et biophysica acta - 15 Apr 2005

Arcasoy Murat O, Karayal Aysen F

Abstract excerpt

Erythropoietin receptor (EPOR) gene mutations leading to truncations of the cytoplasmic, carboxy-terminal region of EPOR have been described in some patients with primary familial and congenital polycythemia (PFCP), a disorder characterized by isolated erythrocytosis and increased sensitivity of erythroid progenitors to Epo. We studied the role of EPOR in the pathogenesis of PFCP and the requirement for...

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Source

Identifiers

PMID: 15878737
DOI: 10.1016/j.bbadis.2005.03.003

Genes

EPOR

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Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain.PMID 15878737Read ↗

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